I recently experimented with hosting my blog on CloudFront. While this was great for performance it caused a few issues.
Cloudflare does not translate /foo to /foo/index.html, which makes perfect
sense for performance; but causes problems if you depend on the server to
follow that lookup pattern.
To fix this I use S3 for zeespencer.com and CloudFront for
assets.zeespencer.com and the
jekyll-cdn gem to provide Liquid
filters so switching between local testing and hosted is a snap.